Altered expression of NFY-C and RORA in colorectal adenocarcinomas

作者：Kottorou Anastasia E; Antonacopoulou Anna G; Dimitrakopoulos Fotinos Ioannis D; Tsamandas Athanasios C; Scopa Chrisoula D; Petsas Theodore; Kalofonos Haralabos P^*

来源：Acta Histochemica, 2012, 114(6): 553-561.

DOI：10.1016/j.acthis.2011.10.005

• mRNA
• Colorectal adenocarcinoma
• Immunohistochemistry
• Clinicopathological characteristics
• Disease progression
• Primary site

NFY-C, a subunit of the transcription factor NFY, binds to the promoters of several eukaryotic genes, including cell cycle-related genes. RORA is a steroid hormone receptor implicated in a range of important cellular processes. We evaluated the expression of NFY-C and RORA in colorectal adenocarcinomas and normal colonic tissue. NFY-C expression was elevated in adenocarcinomas. Moreover, NFY-C mRNA levels correlated with time to disease progression, while NFY-C protein expression was significantly higher in metastatic disease. RORA expression was downregulated in CRC adenocarcinomas compared to normal controls and correlated with time to disease progression. The role of NFY-C and RORA in CRC merits further investigation.

• 出版日期2012