A prototype of giant magnetoimpedance-based biosensing system for targeted detection of gastric cancer cells

作者：Chen, Lei^*; Bao, Chen-Chen; Yang, Hao; Li, Ding; Lei, Chong; Wang, Tao; Hu, Heng-Yao; He, Meng; Zhou, Yong; Cui, Da-Xiang

来源：Biosensors and Bioelectronics, 2011, 26(7): 3246-3253.

DOI：10.1016/j.bios.2010.12.034

• Giant magnetoimpedance
• Gastric cancer cell
• Targeted detection
• Biosensing system
• Prototype

A targeted detection of gastric cancer cells is achieved by combining the giant magnetoimpedance (GMI)-based biosensing system and RGD-4C peptide coupled, chitosan covered superparamagnetic iron oxide particles (RGD-Fe3O4@chitosan). The micro-patterned GMI sensor for targeted detection is made of Co-based ribbon and fabricated by micro electromechanical system (MEMS) technology. Functionalized nanoparticles were designed by coating Fe3O4 with chitosan and conjugating with RGD-4C peptides. The targeted cells were trickled down into the detection area of the system. The detection of each sample is carried out in ten-fold manner and average value is taken as the final result. This system can identify the differences between targeted cells and non-targeted cells. It is of considerable interest due to its potential application in the biomedical field of various specific detections.

• 出版日期2011-3-15
• 单位上海交通大学