科研之友
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摘要
The antineoplastic effect of carfilzomib (CFZ) against chemically induced hepatocarcinogenesis was studied. A total of 60 male Wistar albino rats were divided into six groups with 10 animals in each group. Rats in group 1 (control group) were given dimethylsulphoxide (DMSO) (0.4 mL/kg i.p) twice a week for 3weeks from week8 to week10. Animals in groups 2 and 3 were given CFZ (2 and 4 mg/kg i.p) twice a week from week8 to week10, respectively. Rats in group 4 were given diethylnitrosamine (DENA) at a dose of 0.01% in drinking water for 10 weeks and received a DMSO (0.4 mL/kg i.p) twice a week from week8 to week10. Animals in groups 5 and 6 were given DENA at a dose of 0.01% in drinking water for 10weeks and treated with CFZ (2 and 4 mg/kg i.p) twice a week from week8 to week10, respectively. CFZ succeeded in suppressing the elevated serum tumor marker -fetoprotein and carcinoembryonic antigen. The antineoplastic effect of CFZ was also accompanied by normalization of elevated hepatic tissue growth factors, matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1, and augmentation of hepatic endostatin and metallothionein. A histopathological examination of liver samples treated with CFZ after DENA intoxication correlated with the biochemical observation. Treatment with CFZ confers an antineoplastic activity against chemically induced hepatocarcinogenesis. These findings suggest that CFZ plays a pivotal role in the treatment of hepatocarcinogenesis.
- 出版日期2014-9
