Disrupted daily light-dark cycles induce physical inactivity and enhance weight gain in mice depending on dietary fat intake

作者：Oishi Katsutaka^*; Higo Yamamoto Sayaka

来源：NeuroReport, 2014, 25(11): 865-869.

DOI：10.1097/WNR.0000000000000202

We evaluated associations between obesity induced by a high-fat diet (HFD) and the environmental light-dark (LD) cycle that entrains the master circadian clock located in the suprachiasmatic nucleus of mammals. Mice were fed normal diet or HFD for 6 weeks in individual cages with running wheels under a normal 12 h light-12 h dark cycle (LD 12 : 12) or an ultradian 3 h light-3 h dark cycle (LD 3 : 3) that might perturb the central clock. Circadian behavioral rhythms in mice fed both diets were disrupted by light-induced direct suppression of the behavior (masking effect) under LD 3 : 3. The ultradian LD cycle reduced the total daily activity of wheel running and enhanced body weight gain in the mice fed the HFD. Secondary effects such as obesity are probably not associated with inactivity induced under these circumstances because wheel-running activity decreased markedly within a few days of transfer from LD 12 : 12 to LD 3 : 3. Food consumption was significantly suppressed under LD 3 : 3 in mice fed the HFD. These findings suggest that the aberrant LD cycle induced physical inactivity and enhanced weight gain depending on dietary fat consumption. This might help to explain the higher incidence of obesity among shift workers.

• 出版日期2014-8-6