An Investigation of Candidate Regions for Association With Bipolar Disorder

作者：Knight Jo^*; Rochberg Nanette S; Saccone Scott F; Nurnberger John I Jr; Rice John P

来源：American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 2010, 153B(7): 1292-1297.

DOI：10.1002/ajmg.b.31100

• bipolar disorder
• genetics
• association

We performed a case-control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6 (105-113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P-values of 2 x 10(-5)). Both P-values are in the top 5% of the distribution derived from null simulations (P 0.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP.

• 出版日期2010-10