科研之友
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摘要
Asymmetric hydrosilylation of alkenes, which has been recognized as an important method for the preparations of optically active secondary alcohols, deserves widespread attention over the world. It is reported that such reaction can be catalyzed by Pd-monodentate phosphorus catalysts with excellent reactivity and enantioselectivity. In the past decades, a wide variety of chiral monodentate phosphorus ligands have been developed because of their stable structure, facile synthesis, convenient modification, unique efficiency. Among them, there are three predominant classes of ligands-phosphines based on an axially chiral biaryl scaffold, phosphines based on a planar chiral ferrocene scaffold and chiral phosphoramidites. Herein, the recent advances in asymmetric hydrosilylation of alkyl-substituted alkenes, styrene derivatives, 1,3-dienes and other carbon-carbon double bond compounds catalyzed by palladium monodentate phosphorus catalysts are summarized. The perspective is also discussed.
