Microbial transformations of gelomulide G: A member of the rare class of diterpene lactones

作者：Choudhary MI^*; Gondal HY; Abbaskhan A; Atta ur Rahman

来源：Chemistry and Biodiversity, 2005, 2(10): 1401-1408.

DOI：10.1002/cbdv.200590112

Microbial transformation of gelomulide G (3 beta,6 beta-diacetoxy-8 beta,14 beta-epoxyabiet-13(15)-en-16:12-olide, 1) was carried out. Incubation of 1 with Aspergillus niger afforded two new metabolites, 3 beta,6 beta-diacetoxv-8 beta,14 beta-dihydroxyabiet-13(15)-en-16,12-olide (2) and 3 beta,6 beta-diacetoxy-14#-hydroxyabieta-8(9) 13(15)-dien-16.12-olide (3). While Cunninghamella elegans afforded the 14-epimer of 2. i.e., 3 beta.6 beta-diacetoxy-8 beta,14 alpha-dihydroxvabiet-13(15)-en-16,12-olide (4), along with 3 beta-acetoxy-6 beta-hydroxy-8 beta,14 beta-epoxyabiet-13(15)-en-16,12-olide (5). The structures of the transformed products 2-5 were deduced to be new on the basis of MS and NMR data.

• 出版日期2005