Dy(OTf)(3)/Pybox-catalyzed enantioselective Friedel-Crafts alkylation of indoles with alpha,beta-unsaturated trifluoromethyl ketones

作者：Sasaki Shigeru; Yamauchi Takayasu; Higashiyama Kimio^*

来源：Tetrahedron Letters, 2010, 51(17): 2326-2328.

DOI：10.1016/j.tetlet.2010.02.121

• alpha,beta-Unsaturated trifluoromethyl ketones
• Indoles
• Enantioselective Friedel-Crafts alkylation

The first catalytic enantioselective Friedel-Crafts alkylation of indoles with alpha,beta-unsaturated trifluoromethyl ketones has been accomplished. The reaction was achieved in the presence of the Dy(OTf)(3)/Pybox complex, producing the desired products in high yields (up to 99%) with good enantioselectivities (up to 86% ee). The absolute stereochemistry of the resulting adducts was determined by X-ray analysis.

• 出版日期2010-4-28
• 单位河北医科大学