Anti-Inflammatory and Antioxidant Components from Hygroryza aristata

作者：Chung Yu Ming; Lan Yu Hsuan; Hwang Tsong Long; Leu Yann Lii^*

来源：Molecules, 2011, 16(3): 1917-1927.

DOI：10.3390/molecules16031917

• Hygroryza aristata
• Gramineae
• hygarine
• anti-inflammatory
• antioxidant

Twenty-six known compounds and two new compounds, including a new lignan, (7S*, 8R*, 7' R*, 8' S*)-icariol A(2)-9-O-beta-xylopyranoside (1), and a new indole alkaloid, hygarine (2), were isolated from the extracts of Hygroryza aristata (Gramineae). The structures of all compounds were elucidated on the basis of NMR spectral analysis. The compounds (-)-epigallocatechin-3-O-gallate (4) and (-)-epicatechin-3-O-gallate (5) possess free radical scavenging activities and compound 1 could inhibit superoxide anion generation and elastase release by fMLP/CB-induced human neutrophils with IC(50) values of 19.33 +/- 0.86 and 24.14 +/- 1.59 mu M, respectively.

• 出版日期2011-3
• 单位长春大学; 中国医科大学