An in-tether sulfilimine chiral center induces β-turn conformation in short peptides

作者：Lin, Huacan; Jiang, Yixiang; Hu, Kuan; Zhang, Qingzhou; He, Chuanxin^*; Wang, Tao^*; Li, Zigang^*

来源：Organic and Biomolecular Chemistry, 2016, 14(42): 9993-9999.

DOI：10.1039/c6ob01805j

• RING-CLOSING METATHESIS
• AMINO-ACIDS
• CYCLIC PENTAPEPTIDES
• HELICAL PEPTIDES
• PROTEINS
• DESIGN
• INHIBITORS
• POTENT
• SOMATOSTATIN
• ANTAGONIST

A sulfilimine chiral center in the tether at i, i + 3 positions of short peptides was systematically studied to elucidate the chiralitydriven conformational changes. A rare and unexpected type III beta-turn structure was induced in short peptides by an in-tether chiral center, supported by circular dichroism spectroscopy, NMR and X-ray crystallography.

• 出版日期2016
• 单位北京大学深圳研究生院; 南方科技大学; 深圳大学