An amino acid-based gelator for injectable and multi-responsive hydrogel

作者：Xiong, Wei; Zhou, Hantao; Zhang, Chong; Lu, Hua^*

来源：Chinese Chemical Letters, 2017, 28(11): 2125-2128.

DOI：10.1016/j.cclet.2017.09.019

• Multi-responsive
• Injectable
• Amino acid
• Gelator
• Hydrogel

Hydrogels formed by gelators have attracted growing attention for their promising application in biomaterials and biotechnology. We describe in this paper the generation and characterization of a novel photo-, thermal- and pH-responsive hydrogel based on an amino acid gelator AA-Azo-EG6. Specifically, the gelator bears an amino acid head, an azobenzene (Azo) linker, and a short oligoethylene glycol tail (EG6). The resulting AA-Azo-EG6 hydrogel is injectable and exhibits interesting helical self-assembled structures. Meanwhile, the hydrogel is able to experience a gel-sol or gel-precipitate phase transition responding to external stimuli. Thus, this AA-Azo-EG6 gelator is a promising building block for intelligent materials and drug delivery.

• 出版日期2017-11
• 单位北京大学