New formulations to enhance lovastatin release from red yeast rice (RYR)

作者：Leone Gemma^*; Consumi Marco; Pepi Simone; Lamponi Stefania; Bonechi Claudia; Tamasi Gabriella; Donati Alessandro; Rossi Claudio; Magnani Agnese

来源：JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2016, 36: 110-119.

DOI：10.1016/j.jddst.2016.10.001

• Red yeast rice (RYR)
• Polysaccharides
• Drug delivery systems
• HMG-CoA
• Cholesterol

Nine k-carrageenan/gellan gum formulations have been realized to deliver Red Yeast Rice (RYR). Formulations were characterized by infrared, thermal and rheological analysis. Swelling kinetics and water content (free and bound water) were determined as a function of different composition. Release tests pointed out that formulations obtained combining polymers in a ratio close to 1 (i.e. 40/60 and 50/50) guaranteed a potentiated release of lovastatin from RYR inducing also a superior hypocholesterolemizing action both in terms of hepatocytes cholesterol production and inhibitory activity towards 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA).

• 出版日期2016-12