Lung cancer A modified epigenome

作者：Van Den Broeck Arnaud; Ozenne Peggy; Eymin Beatrice; Gazzeri Sylvie^*

来源：Cell Adhesion and Migration, 2010, 4(1): 107-113.

DOI：10.4161/cam.4.1.10885

• epigenetic
• lung cancer
• DNA methylation
• histone modification

Epigenetic is the study of heritable changes in gene expression that occur without changes in DNA sequence. This process is important for gene expression and genome stability and its disruption is now thought to play a key role in the onset and progression of numerous tumor types. The most studied epigenetic phenomena includes post-translational modifications in DNA and histone proteins as well as microRNRNAs expression. As epigenetic aberrations are potentially reversible, their correction has emerged as a potential strategy for the treatment of cancer. This review highlights the roles of chromatin epigenetic modifications and of microRNRNAs expression in lung tumorigenesis and discusses the emerging epigenetic therapies which are being developed for the treatment of lung cancer.

• 出版日期2010-3