Naturally occurring enzyme inhibitors and their pharmaceutical applications

作者：Ata Athar^*; Naz Samina; Elias Evan M

来源：Pure and Applied Chemistry, 2011, 83(9): 1741-1749.

DOI：10.1351/PAC-CON-10-11-16

• acetylcholinesterase
• antibacterial activity
• Artocarpus nobilis
• Barleria prionitis
• Buxus hyrcana
• B. natalensis
• alpha-glucosidase
• glutathione S-transferase

Enzyme inhibitors play a significant role in the drug discovery process. For instance, acetylcholinesterase (AChE) inhibitors have applications in curing Alzheimer's disease (AD), senile dementia, ataxia, myasthenia gravis, and Parkinson's disease. Glutathione S-transferase (GST) inhibitors have applications as adjuvants to overcome anticancer and antiparasitic drug resistance problems. Compounds inhibiting the activity of alpha-glucosidase are used to treat type 2 diabetes mellitus and obesity problems. This article describes the identification of natural products exhibiting AChE, GST, and alpha-glucosidase inhibitory activities from medicinally important plants. Additionally, structure-activity relationship (SAR) studies of these newly discovered enzyme inhibitors are also discussed.

• 出版日期2011