A facile synthesis of aminomethylene bisphosphonates through rhodium carbenoid mediated N-H insertion reaction. Application to the preparation of powerful uranyl ligands

作者：Lecercle Delphine; Gabillet Sandra; Goinis Jean Marie; Taran Frederic^*

来源：Tetrahedron Letters, 2008, 49(13): 2083-2087.

DOI：10.1016/j.tetlet.2008.01.127

• carbenoids
• insertions
• rhodium
• bisphosphonates
• uranyl

A straightforward procedure ensuring the anchoring of bisphosphonate moiety onto aromatic amines is described. The procedure yields aminoaryl 1,1-bisphosphonates known to display multiple biological activities. The described methodology has also been applied to the synthesis of ligands whose uranyl-binding properties have been studied.

• 出版日期2008-3-24
• 单位中国地震局