The optimal time of B-type natriuretic peptide sampling associated with post-myocardial infarction remodelling after primary percutaneous coronary intervention

作者：Choi Hyunmin^*; Yoo Byung Su; Doh Joon Hyung; Yoon Hee Jeong; Ahn Min Soo; Kim Jang Young; Lee Seung Hwan; Yoon Junghan

来源：Cardiovascular Journal of Africa, 2013, 24(5): 165-170.

DOI：10.5830/CVJA-2013-024

• B-type natriuretic peptide
• remodelling
• myocardial infarction

Aims: To find the optimal time to evaluate plasma B-type natriuretic peptide (BNP), which is related to post-myocardial infarction remodelling (PMIR), we measured serial plasma BNP levels according to time protocols after primary percutaneous coronary intervention (PCI). %26lt;br%26gt;Background: It has been established that plasma BNP levels can predict the development of PMIR in patients with ST-elevation myocardial infarction (STEMI). However, the time of plasma BNP sampling associated with PMIR is still controversial. %26lt;br%26gt;Methods: We analysed 42 patients who were diagnosed as PMIR on six-month follow-up echocardiography among 131 patients with STEMI. We then compared clinical variables including plasma BNP between the remodelling group and the non-remodelling group. The plasma BNP level was obtained on hospital admission (acute phase), at two to five days (early phase), three to four weeks (late phase) and at the six-month follow up (long term). %26lt;br%26gt;Results: Early-phase and long-term BNP levels were higher in the remodelling group. The serial plasma BNP levels, according to study protocols, showed a biphasic pattern of elevation. In multiple logistic regression analyses, early-phase BNP [odds ratio (OR): 1.013, p %26lt; 0.01] and acute-phase BNP levels (OR: 1.007, p = 0.02) were independent predictors of PMIR. However, early-phase BNP level was statistically a more powerful predictor of PMIR during follow up. %26lt;br%26gt;Conclusion: Consecutive BNP levels after primary PCI showed a biphasic peak elevation during follow up. Early-phase plasma BNP level was an independent predictor of PMIR in patients with STEMI.

• 出版日期2013-6