Antiproliferative Effects of Rapamycin and Celecoxib in Angiosarcoma Cell Lines

作者：Bundscherer Annika; Vogt Thomas; Koehl Gudrun; Landthaler Michael; Hafner Christian^*

来源：Anticancer Research, 2010, 30(10): 4017-4023.

• Rapamycin
• mTOR
• celecoxib
• COX 2
• angiosarcoma
• endothelial tumour

Background/Aim: Beyond their primary field of application some well-established drugs exhibit antitumour effects in a variety of cancers. The aim of this study was to investigate the effects of the COX2 inhibitor celecoxib and the mTOR antagonist rapamycin on angiosarcoma cell lines. Materials and Methods: Cell proliferation was measured in ASM, ISOS 1 and ISO HAS angiosarcoma cell lines with the BrdU assay. Results: In all angiosarcoma cell lines, celecoxib as well as rapamycin inhibited cell growth in a dose-dependent manner. In ASM and ISOS 1, but not in ISO HAS angiosarcoma cells, additive growth inhibitory effects were detected by combining both agents. Conclusion: Our results indicate that angiosarcoma cell proliferation can be inhibited by subtoxic doses of rapamycin and celecoxib. Due to their direct and stroma-mediated anticancer activities, mTOR antagonists and COX2 inhibitors represent very promising drugs in the palliative treatment of angiosarcoma.

• 出版日期2010-10