Long non-coding RNAs in non-small cell lung cancer as biomarkers and therapeutic targets

作者：Chen Jing; Wang Rui; Zhang Kai; Chen Long Bang^*

来源：JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2014, 18(12): 2425-2436.

DOI：10.1111/jcmm.12431

• long non-coding RNA
• non-small cell lung cancer
• biomarker
• molecular target

Lung cancer-associated mortality is the most common cause of cancer death worldwide. Non-coding RNAs (ncRNAs), with no protein-coding ability, have multiple biological roles. Long non-coding RNAs (lncRNAs) are a recently characterized class of ncRNAs that are over 200 nucleotides in length. Many lncRNAs have the ability of facilitating or inhibiting the development and progression of tumours, including non-small cell lung cancer (NSCLC). Because of their fundamental roles in regulating gene expression, along with their involvement in the biological mechanisms underlying tumourigenesis, they are a promising class of tissue- and/or blood-based cancer biomarkers. In this review, we highlight the emerging roles of lncRNAs in NSCLC, and discuss their potential clinical applications as diagnostic and prognostic markers and as therapeutic targets.

• 出版日期2014-12
• 单位南京大学