The selective interaction between N-isobutyryl-cysteine enantiomers and L-methotrexate

作者：Chen, Cui; Guo, Liju; Guo, Dongmei; Chen, Ya; Wang, Qinghong; Fu, Yingzi^*

来源：Analytical Methods, 2014, 6(19): 7789-7792.

DOI：10.1039/c4ay01302f

• SELF-ASSEMBLED MONOLAYERS
• GLASSY-CARBON ELECTRODE
• STEREOSPECIFIC INTERACTION
• CHIRAL RECOGNITION
• GOLD ELECTRODES
• AMINO-ACIDS
• HOMOCYSTEINE
• THALIDOMIDE
• SURFACES
• BINDING

Simple and sensitive chiral interfaces were constructed by assembling L- or D-N-isobutyryl-cysteine (NIBC) on a gold electrode surface through an Au-S bond, and the two chiral interfaces were utilized to interact with L-methotrexate (L-Mtx). The surface characteristics and the process of interaction were explored via cyclic voltammetry (CV). The difference in peak current after L-and D-NIBC interacted with L-Mtx reached 525.3 mu A, and a larger current difference was obtained from the L-NIBC interface, suggesting a stereoselective effect between L-Mtx and NIBC enantiomers. Therefore, the chiral NIBC interfaces could not only enhance the electron transfer of L-Mtx, but could also discriminate between NIBC enantiomers.

• 出版日期2014
• 单位西南大学