An improved method for the large scale preparation of alpha,alpha '-trehalose-6-phosphate

作者：Liu Chunliang^*; Mariano Patrick S

来源：Tetrahedron Letters, 2015, 56(23): 3008-3010.

DOI：10.1016/j.tetlet.2014.10.003

• alpha,alpha '-Trehalose-6-phosphate
• Trehalose-6-phosphate phosphatase
• Synthesis
• Selective deprotection

An improved method was developed for the efficient, large-scale synthesis of alpha,alpha'-trehalose-6-phosphate starting with alpha,alpha'-trehalose. In the sequence, octa-trimethylsilylation of alpha,alpha'-trehalose is followed by selective removal of the 6-O-trimethylsilyl protecting group. Reaction of the mono-alcohol with (PhO)(2) POCI is then followed by simultaneous hydrogenolysis and per-desilylation to generate alpha,alpha'-trehalose-6-phosphate, free of contamination by inorganic phosphate.

• 出版日期2015-6-3