Allografting and Xenografting of Testis Tissue and Using Possibilities in the Future

作者：Yilmaz Ayhan^*; Gokdal Ozdal

来源：Kafkas Universitesi Veteriner Fakultesi Dergisi, 2010, 16(6): 1073-1077.

• Spermatogenesis
• Spermatogonia
• Transplantation
• Testis xenografting

The allografting or xenografting of testis tissue pieces into immunodeficient host mice is a new approach for germ cell conserving in livestock production as well as in human medicine. This technique also presents a new approach as a functional assay to study the spermatogenesis process and physiology in domesticated animals and humans; however, some problems observed in xenografted testis tissues remain to be unknown. Xenografts develop a dilated lumen in their seminiferous tubules during grafting period, particularly in xenografting. In addition, xenografts especially have a marked degeneration in advanced meiotic germ cells at the beginning of the grafting and spermatogenesis is reinitiated from spermatogonia stem cells or differentiating spermatogonia. In some species such as human and marmoset, this technique does not result in a complete spermatogenesis. indicating that outcomes of the allografting or xenografting of the testis tissue change according to the species. Despite these main challenges of xenografting of testis tissue, this technique implies a new approach to investigate spermatogenesis process and to solve the infertility problems both in livestock production and human medicine in the future.

• 出版日期2010