Animal Model for Drug-Drug Interaction between Brachyantheraoside A2 and Anti-Glioma Drug Irinotecan

作者：Zhang, Yan-Rui; Chang, Jian; Li, Jin; Huang, Rong; Liu, Peng^*

来源：Latin American Journal of Pharmacy, 2016, 35: 1262-1265.

• animal model
• brachyantheraoside A2
• drug-drug interaction
• human
• irinotecan

Irinotecan is a drug used to treat glioma, and brachyantheraoside A2 is a herbal ingredient to have high possibility to co-dose with irinotecan. Irinotecan-brachyantheraoside A2 interaction has been demonstrated in the previous literature. The present study aims to evaluate which animal model is suitable for prediction of this drug-drug interaction in human. The incubation reaction was performed in human liver microsomes (HLMs), rat liver microsomes (RLMs), mice liver microsomes (MLMs), and dog liver microsomes (DLMs). The results showed that the inhibition potential of brachyantheraoside A2 on the glucuronidation of SN-38 in MLM is the most similar with the situation in HLM. However, inhibition kinetics showed that brachyantheraoside A2 noncompetitively and competitively inhibited the glucuronidation of SN-38 in HLM and MLM, respectively. In conclusion, mice is a good animal model for prediction of brachyantheraoside A2-irinotecan interaction in human. However, the extrapolation of brachyantheraoside A2-irinotecan interaction from mice to human should be given much caution due to the different inhibition type between human and mice.

• 出版日期2016
• 单位新疆医科大学