科研之友
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摘要
The catalytic asymmetric aldol reaction of pyruvic aldehyde dimethyl acetal and 2-acetylthiazole with sugar aldehydes is demonstrated to be the key step in the synthesis of 3-deoxy-2-ulosonic acids. Efficient and stereoselective pyruvate aldol reactions are catalyzed by metal-based chiral Trost and Shibasaki catalysts. The presented synthetic methodology mimics aldolase-catalyzed reactions by direct activation of C3 pyruvate equivalents with the use of metal-based chiral catalysts en route to the synthesis of 2-keto-3-deoxy-D-glucosonic acid and 3-deoxy-D-manno-2-octulosonic acid derivatives.
- 出版日期2012-5
