Systemic mycosis: factors associated with death among patients infected with the human immunodeficiency virus, Cuiaba, State of Mato Grosso, Brazil, 2005-2008

作者：Ribeiro Luciano Correa^*; Hahn Rosane Christine; Favalessa Olivia Cometi; Tadano Tomoko; Fernandes Fontes Cor Jesus

来源：Revista da Sociedade Brasileira de Medicina Tropical, 2009, 42(6): 698-705.

• Human immunodeficiency virus
• Systemic mycosis
• Lethality

Between 2005 and 2008, die prevalence of systemic mycosis among 1,300 HIV/AIDS patients in Cuiaba, Mato Grosso, was 4.6%. The fungus species isolated were Cryptococcus neoformans in 50%, Cryptococcus gattii in 1.6%, Cryptococcus spp in 6.6%, Histoplasma capsulatum in 38.3% and Paracoccidioides brasiliensis in 3.3%. Death was recorded in die cases of 32 patients (53.3%), and cryptococcosis was die main cause. The CD4+ T lymphocyte count was low and similar among patients who survived or died due to systemic mycosis. The factors independently associated with the deaths of these patients were alcoholism (OR: 8.2; 95% CI: 1.4-62.1; p = 0005) and the mean level of lactate dehydrogenase [758 (182) U/l vs. 416 (268) U/l; p < 0001]. The findings showed that systemic mycosis was highly lethal among the patients with HIV/AIDS in Cuiaba and suggested that clinical-laboratory characteristics such as alcoholism and early elevation of lactate dehydrogenase may be factors relating to worse prognosis under these conditions.

• 出版日期2009-12