Nickel-Catalyzed C-H Halogenation of 8-Aminoquinolines for the Synthesis of C(5) and C(7) Di-halogenated Quinolines

作者：Hao, Wenyan^*; Wang, Yuyun; Yang, Guomin; Liu, Yunyun^*

来源：Chinese Journal of Organic Chemistry, 2017, 37(10): 2678-2684.

DOI：10.6023/cjoc201704049

• Nickel-catalyze
• C-H halogenation
• N-bromo-succinimide
• 8-aminoquinolines
• dihalogenated quinoline

A simple and efficient nickel-catalyzed oxidative halogenation (Cl, Br) of C(5) and C(7) C-H bond of 8-aminoquinoline amides has been developed. This method employed low-cost and easy availability nickel as catalyst and oxygen as oxidant. The reactions have good functional groups compatibility, giving highly selective C(5) and C(7) di-halogenated products in good to excellent yields.

• 出版日期2017-10-25
• 单位江西师范大学