An asymmetric approach to bicyclo[2.2.1]heptane-1-carboxylates via a formal [4+2] cycloaddition reaction enabled by organocatalysis

作者：Fu, Jian-Guo; Shan, Yi-Fan; Sun, Wang-Bin; Lin, Guo-Qiang; Sun, Bing-Feng^*

来源：Organic and Biomolecular Chemistry, 2016, 14(23): 5229-5232.

DOI：10.1039/c6ob00814c

• ENANTIOSELECTIVE CONJUGATE ADDITION
• MICHAEL-HENRY REACTION
• ACCESS
• CATALYSTS
• QUATERNARY
• CAMPHOR
• ENONES
• LIGAND
• ACIDS
• MODE

An organocatalytic formal [4 + 2] cycloaddition reaction has been realized that permits rapid access to a wide range of bicyclo[2.2.1] heptane-1-carboxylates in a highly enantioselective manner from simple starting materials under mild and operationally simple conditions.

• 出版日期2016
• 单位中国科学院