N-halamine-decorated polystyrene nanoparticles based on 5-allylbarbituric acid: From controllable fabrication to bactericidal evaluation

作者：Dong, Alideertu^*; Huang, Zhen; Lan, Shi; Wang, Qin; Bao, Sarina; Siriguleng; Zhang, Yanling; Gao, Ge; Liu, Fengqi; Harnoode, Chokto

来源：Journal of Colloid and Interface Science, 2014, 413: 92-99.

DOI：10.1016/j.jcis.2013.09.036

• N-halamine
• Polystyrene
• 5-Allylbarbituric acid
• Controllable fabrication
• Bactericidal

N-halamine-based antibacterial polystyrene nanoparticles with different particle size ranged from 91.5 nm to 562.5 nm were facilely fabricated by surfactant-free emulsion polymerization with 5-allyl-barbituric acid served as N-halamine precursor. Effect of experimental parameters such as monomer concentration, initiator concentration, and ionic strength on particle size was investigated systematically. N-halamine-based antibacterial polystyrene nanoparticles showed enhanced antibacterial activity against both Gram-positive species Staphylococcus aureus and Gram-negative species Pseudomonas aeruginosa compared with bulk powder N-halamine. Biocidal activity of N-halamine-based antibacterial polystyrene nanoparticles can be tailored effectively by tuning particle size. Stability and bactericidal activity of N-halamine-based antibacterial polystyrene nanoparticles was detected as a function of extending period.

• 出版日期2014-1-1
• 单位吉林大学; 内蒙古大学