科研之友
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摘要
Numerous compounds isolated from Ginseng have been shown to exhibit various biological activities, including antioxidant, anti carcinogenic, anti-mutagenic, and anti tumor activities. Recent research has focused on the potential values of these compounds in the prevention and treatment of human cancers. The anti tumor activity of 25-hydroxyprotopanaxadiol (25-OH-PPD), a natural compound isolated from Panax ginseng, has been established in previous study. In the current study, we investigated the antitumor activity of three derivatives of 25-OH-PPD, namely x1, 1c, and 8b with respect to lung cancer. All three compounds significantly inhibited the growth of the human lung cancer cells A549 and H460. Oral administration of these compounds significantly inhibited the growth of xenograft tumors in mice without affecting body weight. Further mechanistic study demonstrated that these compounds could decrease the expression levels of beta-catenin and its downstream targets Cyclin D1, CDK4, and c-myc in lung cancer cells. Taken together, the results suggested that the anti-growth activity exerted by these 25-OH-PPD derivatives against lung cancer cells probably involved beta-catenin-mediated signaling pathway, a finding that could have important implication for chemotherapeutic strategy aiming at the treatment of lung cancer.
