Access to 2,5-Diamidopyrroles and 2,5-Diamidofurans by Au(I)-Catalyzed Double Hydroamination or Hydration of 1,3-Diynes

作者：Kramer Soren; Madsen Julie L H; Rottlander Mario; Skrydstrup Troels^*

来源：Organic Letters, 2010, 12(12): 2758-2761.

DOI：10.1021/ol1008685

A Au(I)-catalyzed hydroamination or hydration of 1,3-diynes to access 2,5-diamidopyrroles and 2,5-diamidofurans has been developed. This method can also be expanded to 2,5-disubstituted furans and 1,2,5-trisubstituted pyrroles including the formation of deuterated heterocycles and O-18-labeled furans.

• 出版日期2010-6-18