Associations Between Hair Manganese Levels and Cognitive, Language, and Motor Development in Preschool Children from Montevideo, Uruguay

作者:Rink Stephanie M; Ardoino Graciela; Queirolo Elena I; Cicariello Daniela; Manay Nelly; Kordas Katarzyna*
来源:Archives of Environmental & Occupational Health, 2014, 69(1): 46-54.
DOI:10.1080/19338244.2012.725229

摘要

Environmental manganese (Mn) exposure in childhood has been associated with developmental deficits. This study investigated associations between low-level Mn exposure and developmental scores in children aged 14-45 months. Children's hair samples (n = 60) were analyzed for Mn and lead (Pb) using inductively coupled plasma mass spectrometry (ICP-MS). Children were assessed with the Bayley Scales of Infant Development III (BSID). Mean hair Mn and Pb concentrations were 0.98 +/- 0.74 and 10.1 +/- 10.5g/g, respectively. Unadjusted inverse associations were seen between Mn and BSID subscales, with girls having lower scores related to Mn than boys. No significant associations remained in covariate-adjusted models, although when stratified by sex boys had a positive association between hair Mn levels and language scores. This study does not show clear evidence of an association between hair Mn concentrations and children's developmental scores in a region of low-level Mn exposure.

  • 出版日期2014-1-2

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