Muscimol as an Ionotropic GABA Receptor Agonist

作者：Johnston Graham A R^*

来源：Neurochemical Research, 2014, 39(10): 1942-1947.

DOI：10.1007/s11064-014-1245-y

• GABA
• Muscimol
• GABA receptors
• GABA transporters

Muscimol, a psychoactive isoxazole from Amanita muscaria and related mushrooms, has proved to be a remarkably selective agonist at ionotropic receptors for the inhibitory neurotransmitter GABA. This historic overview highlights the discovery and development of muscimol and related compounds as a GABA agonist by Danish and Australian neurochemists. Muscimol is widely used as a ligand to probe GABA receptors and was the lead compound in the development of a range of GABAergic agents including nipecotic acid, tiagabine, 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol, (Gaboxadol(A (R))) and 4-PIOL.

• 出版日期2014-10