A comparative study of damage to liver function after TACE with use of low-dose versus conventional-dose of anticancer drugs in hepatocellular carcinoma

作者：Lu Wei^*; Li Yan Hao; Yu Zhi Jian; He Xiao Feng; Chen Yong; Zhao Jian Bo; Zhu Zhi Ying

来源：Hepato-Gastroenterology, 2007, 54(77): 1499-1502.

• carcinoma, hepatocellular
• chemoembolization, therapeutic
• antineoplastic agent
• combined
• liver function

Background/Aims: To study liver function damage after transcatheter arterial chemoembolization (TACE) with use of low-dose versus conventionaldose anticancer drugs in patients with hepatocellular carcinoma (HCC).
Methodology: One hundred and twelve patients with unresectable HCC were randomly divided into two groups to receive superselective TACK Patients in group A (n=52) received low-dose anticancer drugs: mitomycin C (MMC) 2 similar to 8mg, epirubicin (EPI) 5 similar to 10mg and carboplatin (CBP) 100mg were used. Patients in group B (n=60) were given conventionaldose of anticancer drugs (MMC 10mg, EPI 40mg, CBP 300mg). Lipiodol-anticancer drugs emulsion was injected into the feeding arteries of tumors followed by gelatin sponge (GS) or polyvinyl alcohol (PVA) particles embolization. Liver function was evaluated with Child-Pugh scores, total bilirubin (TBIL), albumin (ALB) and alanine aminotransferase (ALT) before TACE, three days, one week (wk) and four wk after procedures.
Results: In both groups, TBIL, ALT, and Child-Pugh scores increased (P<0.001 or P<0.05) and ALB decreased (P<0.001 or P<0.01) three days and one wk after TACE. The different between the parameters obtained four wk after the procedure and baseline parameters was not significant in group A (P>0.05). In group B, however, significant difference (P<0.05) was found in all parameters except ALT.
Conclusions: Superselective TACE with use of low-dose anticancer drugs induces transient impairment in liver function, but use of conventional-dose anticancer drugs can cause lasting, more serious worsening of liver function.

• 出版日期2007-8
• 单位南方医科大学