Utilization of Deceased Donor Kidneys to Initiate Living Donor Chains

作者：Melcher M L; Roberts J P^*; Leichtman A B; Roth A E; Rees M A

来源：American Journal of Transplantation, 2016, 16(5): 1367-1370.

DOI：10.1111/ajt.13740

We propose that some deceased donor (DD) kidneys be allocated to initiate nonsimultaneous extended altruistic donor chains of living donor (LD) kidney transplants to address, in part, the huge disparity between patients on the DD kidney waitlist and available donors. The use of DD kidneys for this purpose would benefit waitlisted candidates in that most patients enrolled in kidney paired donation (KPD) systems are also waitlisted for a DD kidney transplant, and receiving a kidney through the mechanism of KPD will decrease pressure on the DD pool. In addition, a LD kidney usually provides survival potential equal or superior to that of DD kidneys. If KPD chains that are initiated by a DD can end in a donation of an LD kidney to a candidate on the DD waitlist, the quality of the kidney allocated to a waitlisted patient is likely to be improved. We hypothesize that a pilot program would show a positive impact on patients of all ethnicities and blood types.
Recognizing that the number and quality of kidney transplants could be increased to the benefit of waitlisted patients, the authors advocate for the use of some deceased donor kidneys to initiate kidney paired donor chains.

• 出版日期2016-5