Mixed ligand palladium(II) complexes of N-hydroxy-methylsaccharin (Sac-CH2OH): synthesis, characterization and biological studies

作者：Al Jibori Subhi A^*; Al Janabi Ahmed S; Basak Modi Sucharita; Mohamed Samar S; Schmidt Harry

来源：Transition Metal Chemistry, 2015, 40(8): 917-921.

DOI：10.1007/s11243-015-9988-0

Reaction of Na2PdCl4 with two equivalents of N-hydroxymethylsaccharin (Sac-CH2OH) in the presence of NEt3 afforded trans-[Pd(kappa(2)-Sac-CH2O)(2)]. Further reaction of [Pd(kappa(2)-Sac-CH2O)(2)] with one equivalent of diphosphine (L-2), Ph2P(CH2) (n) PPh2, (n = 1, dppm; 2, dppe and 3, dppp), Ph2P(S)(CH2)P(S)Ph-2 (dppmS(2)) or Ph2P(O)(CH2)(2)P(O)Ph-2 (dppeO(2)) afforded mixed ligand complexes [Pd(kappa(1)-Sac-CH2O)(2)(L-2)], while reaction with two equivalents of Ph3P, Ph3PO or Ph3PS (L) gave trans-[Pd(kappa(1)-Sac-CH2O)(2)(L)(2)]. The N-hydroxymethylsaccharinate anion acts as a monodentate ligand, coordinating to the palladium center through the hydroxymethyl oxygen atom. The complexes were characterized by physico-chemical and spectroscopic methods. In addition, the free ligand N-hydroxymethylsaccharin and some of the complexes were screened in vitro for antibacterial activity.

• 出版日期2015-11