A combination of cisplatin-eluting gelatin microspheres and flavopiridol enhances anti-tumour effects in a rabbit VX2 liver tumour model

作者：Nitta N^*; Sonoda A; Seko A; Ohta S; Nagatani Y; Tsuchiya K; Otani H; Tanaka T; Kanasaki S; Takahashi M; Murata K

来源：British Journal of Radiology, 2010, 83(989): 428-432.

DOI：10.1259/bjr/17506834

The aim of this study was to investigate whether the combination of cisplatin-eluting gelatin microspheres (GMSs) and flavopiridol enhances anti-tumour effects in a rabbit VX2 liver tumour model. Tumour-bearing rabbits (n=21) were divided into five groups and infused from the proper hepatic artery. Group 1 (n=5) received cisplatin-eluting GMSs (1 mg kg(-1)) and flavopiridol (3 mg kg(-1)), group 2 (n=5) cisplatin-eluting GMSs alone (1 mg kg(-1)), Group 3 (n=5) flavopiridol (3 mg kg(-1)), Group 4 (n=3) GMSs alone (1 mg kg(-1)), and Group 5 (n=3) was the control group receiving physiological saline (1 ml kg(-1)). On days 0 and 7 after procedures the liver tumour volume was measured using a horizontal open MRI system and the relative tumour volume growth rates for 7 days after treatment were calculated. On T(1) weighted images, the tumours were visualised as circular, low-intensity areas just below the liver surface. After treatment, the signals remained similar. The relative tumour volume growth rate for 7 days after treatment was 54.2+/-22.4% in Group 1, 134.1+/-40.1% in Group 2,166.7+/-48.1% in Group 3, 341.8+/-8.6% in Group 4 and 583.1+/-46.9% in Group 5; the growth rate was significantly lower in Group 1 than the other groups (p<0.05). We concluded that in our rabbit model of liver tumours the combination of cisplatin-eluting GMSs and flavopiridol was effective.

• 出版日期2010-5