An NBD-based colorimetric and fluorescent chemosensor for Zn(2 ) and its use for detection of intracellular zinc ions

作者：Xu Zhaochao; Kim Gun Hee; Han Su Jung; Jou Min Jung; Lee Chongmok^*; Shin Injae; Yoon Juyoung

来源：Tetrahedron, 2009, 65(11): 2307-2312.

DOI：10.1016/j.tet.2009.01.035

A new 7-nitrobenz-2-oxa-1,3-diazole (NBD) based colorimetric and fluorescence chemosensor for Zn(2-), an ion involved in many biological processes, was designed and synthesized. The NBD-probe I displays a red-to-yellow color change and an enhancement of fluorescent intensity in the presence of an aqueous solution of Zn(2 ) ions (pH 7.2). Internal charge transfer (ICT) and photoinduced electron transfer (PET) mechanisms are responsible for these changes. The practical use of this probe was demonstrated by its application to the biologically relevant detection of Zn(2 ) ions in pancreatic beta-cells.

• 出版日期2009-3-14