A Multisite Pilot Study of Extended-Release Injectable Naltrexone Treatment for Previously Opioid-Dependent Parolees and Probationers

作者：Coviello Donna M^*; Cornish James W; Lynch Kevin G; Boney Tamara Y; Clark Cynthia A; Lee Joshua D; Friedmann Peter D; Nunes Edward V; Kinlock Timothy W; Gordon Michael S; Schwartz Robert P; Nuwayser Elie S; O'Brien Charles P

来源：Substance Abuse, 2012, 33(1): 48-59.

DOI：10.1080/08897077.2011.609438

• Extended-release naltrexone
• opioid dependence
• Depotrex
• addiction pharmacotherapy
• offenders
• heroin

A feasibility study was conducted to pilot test the ability of 5 sites to recruit, treat, and retain opioid-dependent offenders in a trial of extended-release injectable naltrexone (XR-NTX). The participants, 61 previously opioid-dependent individuals under legal supervision in the community, received up to 6 monthly injections of Depotrex brand naltrexone and completed a 6-month follow-up interview. Six-month outcomes showed that those who completed treatment had significantly fewer opioid-positive urines and were less likely to have been incarcerated than those who had not completed treatment. The findings indicate that XR-NTX holds promise as a feasible, effective treatment option for opioid-dependent offenders.

• 出版日期2012