Anti-CII antibody as a novel indicator to assess disease activity in systemic lupus erythematosus

作者：He, C.; Mao, T.; Feng, Y.; Song, T.; Qin, C.; Yan, R.; Feng, P.^*

来源：Lupus, 2015, 24(13): 1370-1376.

DOI：10.1177/0961203315588970

• Systemic lupus erythematosus
• disease activity
• anti-collagen type II antibody

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that affects a variety of organ systems. Anti-dsDNA Abs and complement factors have been used as indicators of lupus activity for more than 50 years. A novel indicator of activation in SLE is reported in this paper. Anti-collagen type II (CII) Ab was obviously elevated in patients with SLE compared to those patients with ankylosing spondylitis (AS) and healthy controls (HCs). Anti-CII-Ab-positive patients with SLE showed significantly higher levels of serum IgG and higher titers of ANA but lower levels of C3 and C4 than controls. A positive correlation was demonstrated between anti-CII Ab and serum IgG in SLE patients (r=0.50, p<0.0001). The negative correlations of anti-CII Ab with C3 and C4 were observed in SLE patients (r=-0.36, p=0.0013; r=-0.37, p=0.0006, respectively). The reduced anti-CII Ab level was accompanied by decreased level of serum IgG and increased levels of C3 and C4 after regular treatment. Therefore, anti-CII Ab could be a novel indicator for monitoring activity of SLE.

• 出版日期2015-11
• 单位中国人民解放军第三０二医院; 苏州大学