Diverse functions of uterine proteoglycans in human reproduction (Review)

作者:Kitaya Kotaro*; Tada Yoshihiro; Hayashi Terumi; Taguchi Sagiri; Funabiki Miyako; Nakamura Yoshitaka; Yasuo Tadahiro
来源:Molecular Medicine Reports, 2012, 5(6): 1375-1381.
DOI:10.3892/mmr.2012.826

摘要

Proteoglycans (PGs) are a group of heavily glycosylated proteins that are present throughout the mammalian body and are involved in a wide variety of biological phenomena, including structural maintenance, tissue remodeling, molecular presentation, cell adhesion and signal transmission. Previous studies have revealed an increasing number of roles for PGs in human reproduction. Several PGs are currently utilized or regarded as biomarkers for the diagnosis of certain pathological uterine conditions associated with infertility and obstetrical complications. The aim of this review was to discuss the involvement of PGs in the human uterus in reproductive biology and pathophysiology.

  • 出版日期2012-6