Modulation of cutaneous scavenger receptor B1 levels by exogenous stressors impairs "in vitro" wound closure

作者：Muresan Ximena Maria; Sticozzi Claudia; Belmonte Giuseppe; Savelli Vinno; Evelson Pablo; Valacchi Giuseppe^*

来源：Mechanisms of Ageing and Development, 2018, 172: 78-85.

DOI：10.1016/j.mad.2017.11.006

• Skin
• Oxidative stress
• Pollution
• RHE
• Wound healing
• Particulate matter
• Cigarette smoke
• Ozone

Scavenger receptor B1 (SR-B1) is a trans-membrane protein, involved in tissue reverse cholesterol transport. Several studies have demonstrated that SR-B1 is also implicated in other physiological processes, such as bacteria and apoptotic cells recognition and regulation of intracellular tocopherol and carotenoids levels. Among the tissues where it is localized, SR-B1 has been shown to be significantly expressed in human epidermis. Our group has demonstrated that SR-B1 levels are down-regulated in human cultured keratinocytes by environmental stressors, such as cigarette smoke, via cellular redox imbalance. Our present study aimed to investigate whether such down-regulation was confirmed in a 3D skin model and under other environmental challengers such as particulate matter and ozone. We also investigated the association between oxidation-induced SR-B1 modulation and impaired wound closure. The data obtained showed that not only cigarette, but also the other environmental stressors reduced SR-B1 expression in epidermal cutaneous tissues and that this effect might be involved in impaired wound healing.

• 出版日期2018-6