A Preliminary Result of Treatment of Neuromyelitis Optica With Autologous Peripheral Hematopoietic Stem Cell Transplantation

作者：Peng, Fuhua; Qiu, Wei; Li, Jin; Hu, Xueqiang^*; Huang, Renwei; Lin, Dongjun; Bao, Jian; Jiang, Ying; Bian, Lianfang

来源：Neurologist, 2010, 16(6): 375-378.

DOI：10.1097/NRL.0b013e3181b126e3

• autologous peripheral hematopoietic stem cell transplantation
• neuromyelitis optics
• therapy

Autologous peripheral hematopoietic stem cell transplantation (APHSCT) was performed to treat a patient with neuromyelitis optica. We observed that the patient achieved clinical remission after APHSCT during 12 months of follow-up. The patient improved on the expanded disability status scale neurologic assessment and the Scripps neurologic rating scale worksheet scores on follow-up examination compared with baseline. The MRI abnormalities on T1WI and T2WI improved. The postpartum maternal blood helper T (CD3(+)CD4(+) T cell) and the CD4(+)/CD8(+) ratio were decreased, and the cytotoxic T (CD3(+)CD8(+) T) cell increased. This shows that APHSCT in this patient with neuromyelitis optica appears to reduce the frequency of attacks with improvement in disability. However, a larger study with more patients and a longer follow-up would be required to assess the encouraging preliminary results.

• 出版日期2010-11
• 单位中山大学