A Highly Stereoselective Organocatalytic Tandem Aminoxylation/Aza-Michael Reaction for the Synthesis of Tetrahydro-1,2-Oxazines

作者：Zhu Di; Lu Min; Chua Juan; Tan Bin; Wang Fei; Yang Xinhao; Zhong Guofu^*

来源：Organic Letters, 2008, 10(20): 4585-4588.

DOI：10.1021/ol801864c

A facile stereoselective synthesis of multifunctionalized tetrahydro-1,2-oxazines (THOs) has been achieved by the organocatalyzed asymmetric tandem alpha-aminoxylation/aza-Michael reaction for the C-O/C-N bond formations in moderate to good yields with excellent diastereo- (>99:1 dr) and enantioselectivities (92% to >99% ee).

• 出版日期2008-10-16
• 单位南阳理工学院