A new easily accessible chiral phosphite-phosphoramidite ligand based on 2-anilinoethanol and R-BINOL moieties for Rh-catalyzed asymmetric olefin hydrogenation

作者：Kostas Loannis D^*; Vallianatou Kalliopi A; Holz Jens; Boerner Armin

来源：Tetrahedron Letters, 2008, 49(2): 331-334.

DOI：10.1016/j.tetlet.2007.11.049

• chiral ligand
• phosphite
• phosphoramidite
• BINOL
• asymmetric hydrogenation
• homogeneous catalysis

A novel chiral phosphite-phosphoramidite ligand based on 2-anilinoethanol and R-BINOL moieties has been synthesized in one-pot. The ligand was evaluated in the rhodium-catalyzed enantio selective hydrogenation of alpha- and beta-dehydroamino acid derivatives and dimethyl itaconate in three different solvents at 25 degrees C, at 1 or 50 bar of hydrogen pressure. The solvent and the pressure effect are discussed.

• 出版日期2008-1-7