Association Between Serum 25-Hydroxyvitamin D Levels, Bone Geometry, and Bone Mineral Density in Healthy Older Adults

作者：Mosele Marco; Coin Alessandra; Manzato Enzo; Sarti Silvia; Berton Linda; Bolzetta Francesco; Imoscopi Alessandra; Rinaldi Giulia; Perissinotto Egle; Sergi Giuseppe^*

来源：Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 2013, 68(8): 992-998.

DOI：10.1093/gerona/glt008

• 25-OHD
• Cortical bone area
• Bone density
• Older adults
• pQCT

Purpose. The association between serum 25-hydroxyvitamin D values and cortical/trabecular bone parameters in older adults has been incompletely explored. This study was designed to investigate the relationship between serum 25-hydroxyvitamin D levels and bone parameters for the tibia and radius using peripheral quantitative computed tomography in free-living healthy older adults. %26lt;br%26gt;Methods. The study involved 134 older adults attending a twice-weekly low-intensity fitness program. In addition to clinical history and serum parameters, we assessed fat-free mass using dual-energy X-ray absorptiometry, total bone and cortical bone cross-sectional areas, and trabecular and cortical bone mineral density for the tibia and radius by peripheral quantitative computed tomography. %26lt;br%26gt;Results. After applying multivariate linear regression models, adjusting for sex, age, body mass index, fat mass and fat-free mass, and creatinine, the association between 25-hydroxyvitamin D and bone parameters was significant for total bone and cortical bone cross-sectional areas in the radius (partial R-2 = 0.05 and 0.09, respectively) and for trabecular bone mineral density and cortical bone cross-sectional area in the tibia (partial R-2 = 0.11 and 0.02, respectively). %26lt;br%26gt;Conclusion. These findings support the idea that serum 25-hydroxyvitamin D levels and bone parameters are linked in older adults. Longitudinal studies are needed to establish whether vitamin D levels over time are associated with changes in these parameters.

• 出版日期2013-8