Assessing Treatment Response of Osteolytic Lesions by Manual Volumetry, Automatic Segmentation, and RECIST in Experimental Bone Metastases

作者：Bretschi Maren; Fraenzle Andrea; Merz Maximilian; Hillengass Jens; Semmler Wolfhard; Bendl Rolf; Baeuerle Tobias

来源：Academic Radiology, 2014, 21(9): 1177-1184.

DOI：10.1016/j.acra.2014.04.011

• Bone metastases
• volumetric analysis
• RECIST (responee evaluation criteria in solid tumors)
• therapy response
• CT

Rationale and Objectives: Aim of the study was to compare between volumetric and unidimensional approaches for treatment response. monitoring in a nude rat model of experimental bone metastases. For the volumetric approach, an automated segmentation algorithm-of osteolytic lesions was introduced and compared to-manual volumetry.
Material and Methods: Nude rats bearing osteolytic metastases were treated with zoledronate and sunitinib and compared to controls. Treatment response-was assessed longitudinally in vivo using flat-panel volumetric computed tomography at days 30, 35, 45, and 55-after tumor cell inoculation. The mean sizes and volumes of osteolytic lesions were determined according-to-response evaluation-criteria in solid tumors (RECIST) and by automated and manual volumetry (software: MITK [The Medical Imaging Interaction Toolkit, Heidelberg, Germany] and VIRTUOS, Heidelberg, Germany).
Results: In contrary to RECIST, the manual volumetric approach indicated a significant-decrease in osteolytic lesion volume-in response to treatment. The presented automatic segmentation algorithm for treatment Monitoring identified bone metastases adequately and assessed changes in the osteolytic lesion volume over time according to manual volumetry.
Conclusions: In an animal model, volumetric treatment response assessment of osteolytic bone metastases is superior to unidimensional Measurements; and automated volumetric-segmentation may be a valuable alternative to manual volume determination.

• 出版日期2014-9