A Computational and Cellular Solids Approach to the Stiffness-Based Design of Bone Scaffolds

作者：Norato J A^*; Johnson A J Wagoner

来源：Journal of Biomechanical Engineering, 2011, 133(9): 091003.

DOI：10.1115/1.4004994

• tissue engineering
• bone scaffolds
• cellular solids
• geometry projection
• numerical homogenization
• micro-robotic deposition

We derive a cellular solids approach to the design of bone scaffolds for stiffness and pore size. Specifically, we focus on scaffolds made of stacked, alternating, orthogonal layers of hydroxyapatite rods, such as those obtained via micro-robotic deposition, and aim to determine the rod diameter, spacing and overlap required to obtain specified elastic moduli and pore size. To validate and calibrate the cellular solids model, we employ a finite element model and determine the effective scaffold moduli via numerical homogenization. In order to perform an efficient, automated execution of the numerical studies, we employ a geometry projection method so that analyses corresponding to different scaffold dimensions can be performed on a fixed, non-conforming mesh. Based on the developed model, we provide design charts to aid in the selection of rod diameter, spacing and overlap to be used in the robotic deposition to attain desired elastic moduli and pore size. [DOI: 10.1115/1.4004994]

• 出版日期2011-9