FGF21 Regulates Sweet and Alcohol Preference

作者：Talukdar Saswata; Owen Bryn M; Song Parkyong; Hernandez Genaro; Zhang Yuan; Zhou Yingjiang; Scott William T; Paratala Bhavna; Turner Tod; Smith Andrew; Bernardo Barbara; Mueller Christian P; Tang Hao; Mangelsdorf David J^*; Goodwin Bryan; Kliewer Steven A^*

来源：Cell Metabolism, 2016, 23(2): 344-349.

DOI：10.1016/j.cmet.2015.12.008

Fibroblast growth factor 21 (FGF21) is a hormone induced by various metabolic stresses, including ketogenic and high-carbohydrate diets, that regulates energy homeostasis. In humans, SNPs in and around the FGF21 gene have been associated with macronutrient preference, including carbohydrate, fat, and protein intake. Here we show that FGF21 administration markedly reduces sweet and alcohol preference in mice and sweet preference in cynomolgus monkeys. In mice, these effects require the FGF21 co-receptor beta-Klotho in the central nervous system and correlate with reductions in dopamine concentrations in the nucleus accumbens. Since analogs of FGF21 are currently undergoing clinical evaluation for the treatment of obesity and type 2 diabetes, our findings raise the possibility that FGF21 administration could affect nutrient preference and other reward behaviors in humans.

• 出版日期2016-2-9