Association between maternal serum cytokine profiles at 7-10 weeks' gestation and birthweight in small for gestational age infants

作者：Georgiou Harry M^*; Thio Yulinda S; Russell Chris; Permezel Michael; Heng Yujing J; Lee Stephen; Tong Stephen

来源：American Journal of Obstetrics and Gynecology, 2011, 204(5): 415.e1.

DOI：10.1016/j.ajog.2010.12.005

• cytokine profile
• disease prediction
• inflammatory
• immune system
• small-for-gestational-age

OBJECTIVE: The purpose of this study was to investigate whether birth of a small-for-gestational-age (SGA) baby (birthweight, < 10th percentile) is preceded by altered maternal serum cytokine profiles at early pregnancy, compared with control babies (birthweight, 30-80th percentile).
STUDY DESIGN: A retrospective case-control study of maternal serum collected prospectively across 7-10 weeks of gestation from women attending their first prenatal visit (SGA, 57 cases; control subjects, 71 cases selected retrospectively). Serum concentrations of 27 cytokines were measured in each sample and analyzed by 2-way analysis of variance and non-parametric tests. Logistic regression was used for predictive modeling.
RESULTS: Of 21 detectable cytokines/chemokines, 14 analytes varied significantly (P <= .030) among those women who were destined to de-liver an SGA baby, when compared with control subjects. Of the cytokines that varied in association with SGA, interferon-gamma concentrations increased, and major proinflammatory (interleukin [IL]-2, -7, -12) and antiinflammatory (IL-1 receptor antagonist, -4, -10, -13) cytokine concentrations decreased. Eotaxin and macrophage inflammatory protein-1 alpha were higher; monocyte chemoattractant protein-1 and IL-8 were lower.
CONCLUSION: SGA births may be preceded by altered immune cytokine profiles at 7-10 weeks of gestation.

• 出版日期2011-5