Brain and skull base MRI findings in patients with Ollier-Maffucci disease: A series of 12 patient-cases

作者：Mandonnet Emmanuel^*; Anract Philippe; Martin Elisabeth; Roujeau Thomas; Spena Giannantonio; Cormier Daire Valerie; Duffau Hugues; Baujat Gennevieve

来源：Clinical Neurology and Neurosurgery, 2017, 160: 147-151.

DOI：10.1016/j.clineuro.2017.07.011

• Ollier-Maffucci
• MRI
• Glioma
• Chondrosarcoma
• IDH mutation

Objectives: To estimate the prevalence rate of silent cranial and intracranial lesions in a series of Ollier-Maffucci patients.
Patients and methods: Cerebral MRI was routinely performed in Ollier-Maffucci patients followed-up in our tertiary centers. Patients with previous history of skull base or intracranial tumors were excluded from the study.
Clinical and radiological datas were retrospectively collected. The occurrence rate and nature of abnormal cerebral MRIs were determined.
Results: Twelve patients were included. A glioma-looking lesion was found in one patient (8%), while skull base lesions were evidenced in 3 others (25%). A regular MRI follow-up was recommended for each patient, with a time interval varying between 1 year and 3 years depending on the likelihood of tumoral evolutivity, as infered from the MRI findings.
Conclusion: All in all, the high rate of intracranial and skull base lesions with a malignant potential warrants to include cerebral MRI in the routine follow-up of Ollier-Maffucci patients.

• 出版日期2017-9