Discovery of the First Environment-Sensitive Fluorescent Probe for GPR120 (FFA4) Imaging

作者：Liu, Jiaxiang; Tian, Chengsen; Jiang, Tianyu; Gao, Yuqi; Zhou, Yubin; Li, Minyong; Du, Lupei^*

来源：ACS Medicinal Chemistry Letters, 2017, 8(4): 428-432.

DOI：10.1021/acsmedchemlett.7b00023

• GPR120
• fluorescent probes
• cell imaging
• subcellular localization

GPR120, which is activated by long-chain free fatty acids (FFAs), 'has been recognized as a new attractive target for the treatment of type 2 diabetes and metabolic disease. The visualiiation and location of GPR120 in native cells can provide powerful information for guiding the physiological and pathological studies of GPR120. We report herein the first potent fluorescent probes that sensitively detect GPR120. We designed and synthesized a series of novel environment-sensitive probes with suitable fluorescence property, high biological activity on the GPR120, and acceptable cytotoxicity. These fluorescent probes targeting GPR120 are expected to expand the toolkit for further studies on GPR120.

• 出版日期2017-4
• 单位齐鲁师范学院; 山东大学